منابع مشابه
Bone marrow dosimetry using 124I-PET.
UNLABELLED Bone marrow is usually dose-limiting for radioimmunotherapy. In this study, we directly estimated red marrow activity concentration and the self-dose component of absorbed radiation dose to red marrow based on PET/CT of 2 different (124)I-labeled antibodies (cG250 and huA33) and compared the results with plasma activity concentration and plasma-based dose estimates. METHODS Two gro...
متن کامل124I PET and 3-Dimensional–Internal Dosimetry (3D–ID) Software
1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York; 2Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York; 3Department of Nuclear Medicine, Philips-University of Marburg, Marburg, Germany; 4Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; and 5Department of Radiology, School of Medicine, Jo...
متن کاملPatient-specific dosimetry for 131I thyroid cancer therapy using 124I PET and 3-dimensional-internal dosimetry (3D-ID) software.
UNLABELLED Compared with conventional, whole-organ, S-factor-based dosimetry, 3-dimensional (3D), patient-specific dosimetry better accounts for radionuclide distribution and anatomic patient variability. Its accuracy, however, is limited by the quality of the cumulated activity information that is provided as input. This input has typically been obtained from SPECT and planar imaging studies. ...
متن کاملOptimized 124I PET dosimetry protocol for radioiodine therapy of differentiated thyroid cancer.
UNLABELLED Iodine kinetics and lesion dose per administered 131I activity (LDpA) of differentiated thyroid cancer metastases were determined using 124I PET. These data were analyzed to derive an optimized dosimetry protocol. METHODS We evaluated the time-activity-concentration curves of 37 lesions in 17 patients who had undergone thyroidectomies. LDpA determination involved 124I PET images ac...
متن کامل4 PET / CT derived whole body and bone marrow dosimetry of 89 Zr - cetuximab
PET/CT imaging allows for image based estimates of organ and red marrow (RM) residence times. The aim of this study was to derive PET/CT based radiation dosimetry for Zr-cetuximab, with special emphasis on determining RM absorbed dose. Methods: Seven patients with colorectal cancer received 36.9 ± 0.8 MBq Zr-cetuximab within 2 h after administration of a therapeutic dose of 500 mg⋅m of cetuxima...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2012
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.111.096453